Computational modeling across scales in research and education
You are cordially invited to the lecture: Computational modeling across scales in research and education
Invited lecture: Tomas Helikar, Ph.D., Department of Biochemistry, University of Nebraska-Lincoln, USAWhen: December 19th, 2019, 14:00
Where: seminar room T12/SE 4.166, 4th floor, Department of Biomedical Engineering (UBMI), FEEC, BUT, Technicka 12, Brno
Abstract
Biological processes across organisms are governed by complex, nonlinear network systems that span multiple layers of biological organization, from molecular to cellular to organ and organismal levels. Mathematical and computational modeling has become integral to better understanding the systems’ mechanism and dynamics under healthy as well as diseased conditions. In this presentation, discussed will be our efforts in studying the human immune system through the lens of multi-scale and multi-approach computational models. In particular, I will focus on our recent integrative models that revealed specific mechanisms of controlling the differentiation pattern of CD4+ T cells, as well as metabolic targets for repurposable drugs for several autoimmune diseases. Furthermore, discussed will be our technology-driven efforts to address the challenges associated with constructing comprehensive, accurate, and re-usable mathematical models. Finally, presented will be our work towards making computational modeling and simulation an effective learning and teaching tool in (non-computational) biology and biochemistry courses. Specifically, we have developed an approach and software tools that makes modeling accessible to anyone with or without computational background, and enables life sciences students to learn about the mechanism and dynamics of biological processes by building, simulating, and breaking computational models embedded in these systems.
About the lecturer:
Dr. Helikar is an Associate Professor in the Department of Biochemistry at the University of Nebraska-Lincoln. Dr. Helikar holds courtesy appointments as an Associate Professor in the Department of Computer Science and Engineering and the Department of Pharmacology and Experimental Neuroscience. Dr. Helikar’s group focuses on the use of computational, multi-scale, multi-cellular systems modeling and high-throughput data analysis to improve our understanding of mechanisms and dynamics of complex biological networks that govern the healthy state of an organism, how aberrant changes in these networks result in diseases, and how we can strategically develop more effective therapies to challenge these diseases. His group also aims to transform the way life sciences students learn about complex living systems by developing, implementing, and evaluating computational modeling and computer simulations as a unique and user-friendly pedagogical aid. Dr. Helikar’s research program has been funded by various U.S. federal agencies, including the National Science Foundation (NSF), National Institutes of Health (NIH), and the Department of Defense (DoD), as well as private sponsors, including Google, LLC.
Photo: Nebraska Today: https://news.unl.edu/newsrooms/today/article/immune-system-modeling-gets-boost/
Odpovědná osoba | Mgr. et Bc. Lenka Gumulec |
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Datum publikování |
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